Late 19th century; earliest use found in The New Sydenham Society's Lexicon of Medicine and the Allied Sciences. From mono- + substituted, after monosubstitution.
Definition of monosubstituted in US English:
monosubstituted
adjective
Chemistry
Formed by or exhibiting monosubstitution.
Origin
Late 19th century; earliest use found in The New Sydenham Society's Lexicon of Medicine and the Allied Sciences. From mono- + substituted, after monosubstitution.