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单词 probenecid
释义

Definition of probenecid in English:

probenecid

noun prəʊˈbɛnɪsɪdprōˈbenəsəd
mass nounMedicine
  • A synthetic sulphur-containing compound which promotes increased excretion of uric acid and is used to treat gout.

    〔医〕对二丙磺胺氨基苯甲酸,丙黄舒,羧苯磺胺

    Example sentencesExamples
    • Administration of this drug with probenecid should be avoided as it has been found to inhibit the renal excretion of meropenem.
    • To decrease the potential for nephrotoxicity, coadministration of probenecid and hydration with 0.9% sodium chloride is required.
    • There are two classes of drugs to reduce uric acid: uricosurics, such as probenecid, which increases excretion, and xanthine oxidase inhibitors, such as allopurinol, which reduce production.
    • Scientists found that a simple benzoic acid derivative called probenecid stops many drugs, including antibiotics, being removed from the blood by the kidneys.
    • Parenteral treatment refused: amoxycillin 500 mg four times a day plus probenecid 500 mg four times a day for 14 days

Origin

1950s: from pro(pyl) + ben(zoic) + -e- + (a)cid.

Definition of probenecid in US English:

probenecid

nounprōˈbenəsəd
Medicine
  • A synthetic compound that promotes increased excretion of uric acid and is used to treat gout.

    〔医〕对二丙磺胺氨基苯甲酸,丙黄舒,羧苯磺胺

    Chemical formula C₁₃H₁₉NO₄S

    Example sentencesExamples
    • There are two classes of drugs to reduce uric acid: uricosurics, such as probenecid, which increases excretion, and xanthine oxidase inhibitors, such as allopurinol, which reduce production.
    • Scientists found that a simple benzoic acid derivative called probenecid stops many drugs, including antibiotics, being removed from the blood by the kidneys.
    • To decrease the potential for nephrotoxicity, coadministration of probenecid and hydration with 0.9% sodium chloride is required.
    • Administration of this drug with probenecid should be avoided as it has been found to inhibit the renal excretion of meropenem.
    • Parenteral treatment refused: amoxycillin 500 mg four times a day plus probenecid 500 mg four times a day for 14 days

Origin

1950s: from pro(pyl) + ben(zoic) + -e- + (a)cid.

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更新时间:2025/7/6 7:36:17