A part of a molecular structure that is responsible for a particular biological or pharmacological interaction that it undergoes.
药效团
Example sentencesExamples
The similar mechanism of action of paclitaxel, the epothilones, discodermolide and eleutherobin has led to the suggestion that these structurally dissimilar substances possess common pharmacophores.
For beta 1 selectivity, a beta-adrenergic antagonist should contain a p-substituted aryloxypropanolamine pharmacophore.
The particular parts of a drug that cause it to bind to its receptor are together termed the pharmacophore.
The phenothiazine ring is a well-known pharmacophore, and chlorpromazine is a prototype of this class of antipsychotic drugs.
This pharmacophore identifies two important hydrogen-bonding interactions at opposite ends of the ligand.
Definition of pharmacophore in US English:
pharmacophore
nounˈfärməkəˌfôr
A part of a molecular structure that is responsible for a particular biological or pharmacological interaction that it undergoes.
药效团
Example sentencesExamples
For beta 1 selectivity, a beta-adrenergic antagonist should contain a p-substituted aryloxypropanolamine pharmacophore.
The phenothiazine ring is a well-known pharmacophore, and chlorpromazine is a prototype of this class of antipsychotic drugs.
This pharmacophore identifies two important hydrogen-bonding interactions at opposite ends of the ligand.
The particular parts of a drug that cause it to bind to its receptor are together termed the pharmacophore.
The similar mechanism of action of paclitaxel, the epothilones, discodermolide and eleutherobin has led to the suggestion that these structurally dissimilar substances possess common pharmacophores.