A major genetic mutation, especially as a postulated cause or significant contributory factor in the evolution of new taxa; a mutation which causes a large shift in phenotype.
Origin
1940s. From macro- + mutation. Compare micromutation.
Definition of macromutation in US English:
macromutation
nounˌmakrəʊmjuːˈteɪʃn
Biology
A major genetic mutation, especially as a postulated cause or significant contributory factor in the evolution of new taxa; a mutation which causes a large shift in phenotype.
Origin
1940s. From macro- + mutation. Compare micromutation.